The term sickle cell trait is used for the condition characterized by the presence of normal adult hemoglobin (Hb A) and sickle hemoglobin (Hb S) in an individual’s hemoglobin make-up. Sickle cell trait is the carrier state of the disease. People with the trait are usually healthy and experience little or no discomfort due to the sickle cell hemoglobin.
Hemoglobin C is another type of hemoglobin slightly different from the normal. Hemoglobin C does not sickle. About 1 in 50 African Americans may carry the C trait. These persons experience no problems. However, there is a 25% chance of a couple , one with Hemoglobin C and the other with Hemoglobin S transmitting anemia SC, a variant form of Sickle Cell anemia to their child. Sickle Cell Anemia (SC) is less severe than Sickle Cell Anemia (SS).
Sickle hemoglobin is a type of abnormal hemoglobin that is inherited by children from their parents. It differs from the normal adult hemoglobin (Hb A) in that there is a chemical substitution in the protein portion of the hemoglobin molecule.
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